Biomedical Technology

Health Gene Limited

🌍 Official Website 🏢 HKSTP Source
62 Potential

Decision Maker

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info@healthgene.com.hk
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Raw Description
Product | Health Gene will provide research in diagnosis of cancers and the following: | (1) F18-PSMA (prostate-specific membrane antigen) for diagnosis of prostate cancer: | Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in all types of prostatic tissue, but with increased PSMA expression in prostate cancer tissue. Ga-68 or F-18 labeled PSMA has been developed as an imaging agent for prostate cancer patient. F-18 labeled PSMA would provide a better alternative because of its longer half life (2 hrs) and much higher yield , thus can be produced in large amounts per batch, enabling services to multiple clinics, and benefiting many more patients. | (2) Ga-68 DOTA compounds used for diagnosis of neuro-endocrine tumors: | Neuroendocrine tumors (NETs) are tumors arising from the neuroendocrine cells dispersed through the body derived from the neural crest, and with increased expression of somatostatin receptor on cell membrane. The incidence of these tumors is rising. Ga-68 labeled somatostatin analogues such as DOTATATE are developed as PET tracers for NETs and have shown excellent results in management of NET such as diagnosis, staging, selection of therapy candidates and monitoring therapy response. | (3) F-18 FMC (fluoro-methyl-choline) for diagnosis of liver cancer: | Hepatocellular carcinoma (HCC) is highly malignant and deadly. The sensitivity of routine 18F-FDG PET for detecting HCC is poor. Choline is an essential component in synthesis of cell membrane, which is essential in metabolism of HCC. There is an increased uptake of choline into HCC. F-18 FMC has been proposed as a better method for the detection of HCC. Dual tracers PET/CT scan using FMC and FDG can improve HCC detection sensitivity to as high as 94%. | (4) FET for diagnosis of brain cancer: | 18F-FET PET has shown value in the diagnosis of brain tumor recurrence after initial surgery or radiotherapy and for directing biopsy or radiosurgery. || Health Gene is a leading medical diagnostic and research company which participates in the "Pilot Project on Enhancing Radiological Investigation Services" through collaboration with the Hong Kong Cyclotron Laboratories Limited in Hong Kong Science Park.

Strategic Analysis

Executive Brief

Health Gene Limited is a specialized medical diagnostic and research entity focused on the production and clinical application of radiopharmaceuticals for PET/CT imaging. They operate at the intersection of nuclear medicine and oncology, specifically utilizing cyclotron-produced isotopes like F-18 and Ga-68 to synthesize tracers (PSMA, DOTATATE, FMC, FET). Their operations require high-precision chemical synthesis, extreme radiation environments, and sophisticated thermal management during isotope production.

Strategic Fit & Lead Score

Lead Score: 62/100

  • Why this Score? While Health Gene is a medical service provider, their reliance on cyclotron technology and radio-synthesis presents a significant "Extreme Environment" engineering challenge. Diamond is the premier material for cyclotron target windows, radiation-hard detectors, and electrochemical processing of isotopes. Their partnership with Hong Kong Cyclotron Laboratories indicates a need for high-uptime, high-flux production hardware where 6C's materials provide a competitive edge over standard metals or ceramics.

6C Solutions Proposal

Application Area 6C Solution Technical Value Prop
Cyclotron Target Windows PCD (Polycrystalline) Diamond Replaces Havar or Aluminum foils. Diamond’s high thermal conductivity (2000 W/mK) allows for higher beam currents and shorter irradiation times without melting the target window.
Radiation Monitoring SCD (Single Crystal) Detectors Ultra-wide bandgap (5.5 eV) ensures low leakage current and extreme radiation hardness. Enables real-time, in-situ beam profiling and dose monitoring for F-18/Ga-68 production without sensor degradation.
Radio-Synthesis Sensors BDD (Boron Doped Diamond) BDD electrodes offer the widest electrochemical potential window. Ideal for the electrochemical synthesis of precursors or sensing impurities in high-activity radiopharmaceutical batches.
Heat Dissipation PCD Heat Spreaders Used in the cooling blocks of automated synthesis modules. Diamond's thermal expansion coefficient matches well with high-power electronics used in cyclotron control systems.
High Purity Hydrogen 6C H2 Generators Provides 9N purity (99.9999999%) Hydrogen gas. Critical for maintaining a reducing atmosphere in specialized chemical reactors used for tracer labeling and preventing oxidative degradation.

Engagement Hooks

  • Technical Question: "As you scale F-18 production to serve multiple clinics, are you facing beam-current limitations on your cyclotron targets due to the thermal constraints of standard foil windows?"
  • Value Statement: "6C can help Health Gene increase tracer yield and system reliability by integrating CVD diamond components that withstand the extreme heat and radiation flux of high-output isotope production."

Technical Capabilities Cross-Reference

  • Material Grades:
    • Electronic Grade SCD: Nitrogen content < 5 ppb for radiation sensing.
    • Thermal Grade PCD: Thermal conductivity > 1800 W/mK for target cooling.
    • BDD Electrodes: Tailored doping levels for specific redox reactions in radio-chemistry.
  • Surface Prep: Ra < 1nm polishing available for optical-grade detector interfaces.
  • Scalability: Ability to provide > 5" PCD wafers for large-scale cooling plates or multi-target cyclotron arrays.