Biomedical Technology

Aptacure Therapeutics Limited

🌍 Official Website 🏢 HKSTP Source
55 Potential

Decision Maker

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enquiry.marketing@hkstp.org
+852 2629 1818
5/F, Building 5E, 5 Science Park East Avenue, Hong Kong Science Park
Raw Description
Aptacure Therapeutics Limited (Aptacure) is a biotechnology company based in Hong Kong Science Park. The core technology is originated from more than ten years research in Professor Zhang Ge’s group in Hong Kong Baptist University. The company is aim to develop aptamer-based innovative drugs to treat bone disease and other unmet medical need. | For the leading program Apc001, it is targeted sclerostin to increase the bone anabolic effect. The potential indication includes osteogenesis imperfecta, osteoporosis, fracture healing, etc. Apc001 has been granted Orphan Drug Designation for treating osteogenesis imperfecta by US FDA in 2019. The second program Apc002, is developed for treating bone metastasis, gastric cancer and esophagus cancer, it is in discovery phase. || Product | Aptamers, often termed chemical antibody, are short single stranded oligonucleotides which possess similar affinity and specificity to protein targets compared to monoclonal antibodies, but have advantages in no immunogenicity, easy production, low cost and high stability. It is considered as a promising alternative to monoclonal antibody. | Aptacure currently became a full aptamer drug development platform integrated the knowledge from company talents, local institutes, and industry partners. The platform includes aptamer screening, modification, in vitro functional assessment, in vivo animal efficacy study, upscale manufacturing, IND-enabling studies, and regulatory affairs.

Strategic Analysis

Executive Brief

Aptacure Therapeutics is a clinical-stage biotechnology firm specializing in aptamer-based therapeutics (chemical antibodies) for bone diseases and oncology. Their platform covers the entire lifecycle of drug development—from high-throughput screening and chemical modification to in vivo efficacy—aiming to replace traditional monoclonal antibodies with more stable, cost-effective oligonucleotide solutions.

Strategic Fit & Lead Score

Lead Score: 55 (40-59: General Research / Engineering)

Why this Score? While Aptacure is primarily a pharmaceutical entity, their "Full Aptamer Development Platform" relies heavily on high-sensitivity screening and analytical characterization. 6C’s Boron Doped Diamond (BDD) and SCD surfaces offer a transformative upgrade for electrochemical aptasensors and bio-interfacing, providing superior stability and sensitivity compared to traditional gold or carbon electrodes used in drug discovery.

6C Solutions Proposal

Application Area 6C Solution Technical Value Prop
Electrochemical Aptasensors BDD (Boron Doped Diamond) Electrodes BDD offers the widest electrochemical potential window and lowest background noise of any material, enabling ultra-sensitive detection of aptamer-protein binding kinetics during screening.
Surface Functionalization SCD/PCD Bio-Substrates Diamond's carbon-based lattice allows for stable, covalent C-C bonding of aptamers. Unlike gold (Thiol-linkages), diamond-bonded aptamers do not degrade over time or under varying pH/temperature.
Structural Analysis Optical Grade PCD Windows For IR/Raman spectroscopy used in aptamer folding and modification studies, diamond windows provide the highest thermal conductivity and widest spectral transparency (UV to Far-IR).
Microfluidic Lab-on-Chip Direct Diamond Coating Coating microfluidic channels with diamond creates a chemically inert, biocompatible environment that prevents non-specific protein adsorption during in vitro functional assessments.

Engagement Hooks

  • Technical Question: "As you scale your aptamer screening platform, are you finding that traditional gold or carbon-based electrochemical sensors suffer from signal drift or electrode fouling during complex serum analysis? Would a BDD-based electrode with a wider potential window improve your limit of detection (LoD) for small-molecule targets?"
  • Value Statement: "6C can provide the carbon-based diamond substrates necessary to create the world’s most stable bio-interfaces, ensuring your aptamer-based diagnostics and screening tools are as robust and reproducible as the drugs you are developing."